trouble with win10 (x64) MLJ 2.95 & USB DMX

Hello,
Sorry for your trouble

Both M-DMX & the older grey box, are still supported, with the latest Windows 10 build (1703)
have a look here, for LJ HW compatibility chart:

Depending on your Windows OS, if using latest Windows 10, please install the latest LJ build (2.110.5), posted on the LJ product page: